The present evaluation sets this principle versus the evo-devo three-nose theory, in which nasal polyposis is differentiated as particular to the olfactory nose and in specific to the non-olfactory mucosa of the ethmoid, which is thought about to be not a sinus however rather the skull-base bone harboring the olfactory mucosa. The evo-devo technique allows accurate and easy favorable medical diagnosis of nasal polyposis and its numerous scientific kinds, enhances differential medical diagnosis by identifying persistent illness of the breathing nose and those of the paranasal sinuses, assumes an autoimmune origin particularly intended at olfactory system auto-antigens, and supports the surgical idea of nasalization versus that of practical sinus and ostiomeatal-complex surgical treatment. The ventilation function of the sinuses appears small compared to their production, storage and active release of nitric oxide (NO) serving to oxygenate arterial blood in the lung alveoli.
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